Taking up TOP

Lucas Pelkmans: Taking it from the top

E ndocytic pathways in mammalian cells are too varied and complex to ever be fully understood by traditional cell biological methods, thinks Lucas Pelkmans. Instead, data-driven omics approaches and mathematical mod-eling will be more effective in revealing how the endocytic system works as a whole. Crucial to Pelkmans' studies are mammalian viruses, which enter and infect cells via many differ...

Bottom-up, top-down

Cleaning-up WordNet's Top-Level

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Bottom-Up Beats Top-Down

In PEPA, the calculation of the transitions enabled by a process accounts for a large part of the time for the state space exploration of the underlying Markov chain. Unlike other approaches based on recursion, we present a new technique that is iterative—it traverses the process’ binary tree from the sequential components at the leaves up to the root. Empirical results shows that this algorith...

Taking Up the Cudgels Against Gay Rights?

Against the background of the HIV epidemic and the intense public controversy on homosexuality in African societies, this article investigates the discourses of academic African Christian theologians on homosexuality. Distinguishing some major strands in African theology, that is, inculturation, liberation, women’s and reconstruction theology, the article examines how the central concepts of cu...